George J. Netto, M.D. is Professor and Chair of Pathology at The University of Alabama at Birmingham (UAB). Prior to joining UAB, Dr. Netto was a Professor of Pathology, Urology and Oncology at Johns Hopkins University where he served as the director of Surgical Pathology Molecular Diagnostics. He received his medical degree from the Damascus University Faculty of Medicine in Syria followed by his residency training in Pathology at Baylor University Medical Center in Dallas, Texas. Directly following, he pursued a fellowship in Anatomic Pathology at the Washington University School of Medicine and the Ackerman’s Laboratory of Pathology at Barnes Hospital in St. Louis, Missouri. Dr. Netto then completed a second fellowship in Urologic Pathology at the Memorial Sloan Kettering Cancer Center in New York City.
Dr. Netto is recognized throughout the United States and around the globe for his expertise as a clinician, scholarly educator, and physician-scientist whose research is focused on urologic and molecular diagnostic pathology. His team helped characterize the incidence and role of TMPRSS2-ERG fusion as a prognostic biomarker in prostate adenocarcinoma and its variants. The findings facilitated the utilization of this biomarker in routine needle biopsy specimens together with PTEN, as an adjunct to tumor grade and extent, in clinical management decision-making. In collaboration with the Vogelstein laboratory at Hopkins, Dr. Netto’s team is credited with the important discovery related to the high incidence of TERT gene promoter mutation in muscle invasive bladder cancer and upper tract urothelial carcinoma. They subsequently revealed that the mutation occurs in all precursor lesions of invasive bladder cancer. The discovery led to to the development of a novel non invasive urine based genetic assay for early detection of bladder cancer that promises significant decrease in in the need for repeated invasive and costly cystoscopy procedures.
Dr. Netto is associate editor of the Vircow Archives European Journal od Pathology , associate editor for translation and basic science for the journal “Urology” and the associate editor for the journal “Urology Case Report” and serves on the editorial boards of the journals of “Human Pathology”, “Pathology” and “Advances in Anatomic Pathology”. He has authored or co-authored more than 325 articles and chapters which have been published in peer-reviewed medical journals. He has co-authored four books in urologic pathology and is the editor of a widely recognized textbook on genomics in pathology titled “Genomic Applications in Pathology”. Dr. Netto is frequently requested to speak at national and international lectures in the fields of urologic oncology and molecular and genomic diagnostics